Article révisé par les pairs
Résumé : Preimplantation diagnosis is an early form of prenatal diagnosis, where preimplantation embryos obtained through IVF are analyzed for genetic diseases. This can be done using the polymerase chain reaction (PCR) in the case of monogenetic diseases such as cystic fibrosis (CF), or by fluorescent in situ hybridization (FISH) to determine aneuploidy or gender. Only embryos shown to be free of the disease are transferred to the mother, thus avoiding the termination of pregnancy of a possibly affected foetus. In 1992 we decided to start our own preimplantation diagnosis programme. Here we report the results we have obtained to date.