par Van Der Auwera, Bart;Van Roy, Nadine;De Paepe, Anne;Hawkins, Julie Ross;Liebaers, Ingeborg 
;Castedo, Sérgio M M J S.;Dumon, Jan;Speleman, Frank
Référence Human genetics, 89, 1, page (23-28)
Publication Publié, 1992-04
;Castedo, Sérgio M M J S.;Dumon, Jan;Speleman, FrankRéférence Human genetics, 89, 1, page (23-28)
Publication Publié, 1992-04
Article révisé par les pairs
| Résumé : | XX maleness is the most common condition in which testes develop in the absence of a cytogenetically detectable Y chromosome. Using molecular techniques, it is possible to detect Yp sequences in the majority of XX males. In this study, we could detect Y-specific sequences, including the sex-determining region of the Y chromosome (SRY), using fluorescence in situ hybridization. In 5 out of 6 previously unpublished XX males, SRY was translocated onto the terminal part of an X chromosome. This is the first report in which translocation of an SRY-bearing fragment to an X chromosome in XX males could be directly demonstrated. © 1992 Springer-Verlag. |
