• Citer

Evidence for three glutamic acid transporting systems with specialized physiological functions in Saccharomyces cerevisiae

par Darte, Claude ;Grenson, Marcelle
Référence Biochemical and biophysical research communications, 67, 3, page (1028-1033)
Publication Publié, 1975-12

Article révisé par les pairs

• Accès en ligne
• Détails
• Contenu
• Statistiques

Résumé :

A set of three glutamate uptake systems with different specificities and regulatory properties allows the wild-type yeast Σ1278b to use external glutamate for different functions under different physiological conditions. One of these uptake systems is the general amino acid permease. The two other systems transport dicarboxylic amino acids with much higher specificity. One of them is constitutive in cells grown on NH4+; its activity is inhibited in washed cells coming from a growth medium containing glutamate and NH4+ simultaneously. The rate of synthesis of the third permease is strongly reduced in the presence of NH4+, except in gdhA- mutants. In cells grown on glutamate, the formation of this system is not affected, but its activity is inhibited. © 1975.