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Hyperthermic isolation perfusion with melphalan. A preliminary appraisal of local and general effects in malignant melanoma

par Lejeune, Ferdinand ;Mathieu, Mélanie;Kenis, Yvon
Référence Tumori, 63, 3, page (289-298)
Publication Publié, 1977

Article révisé par les pairs

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Résumé :

Ten hyperthermic isolation-perfusions with melphalan were performed for invasive malignant melanoma of the limbs. Four cases at stage II and with in transit metastases (up to 15 cm in diameter) had a complete regression. However, no improvement of survival was noticed: 4 out of 5 stage II patients who died, within 1 year after perfusion, developed a generalized disease. Systemic chemotherapy was administered in 3 patients after perfusion, but they died from distant metastases. The need for an adequate adjuvant treatment added to isolation perfusion is discussed.