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Influence of nicotinic acid on the rates of turnover and oxidation of plasma glucose in man

par Balasse, Edmond ;Neef, Maria
Référence Metabolism, clinical and experimental, 22, 9, page (1193-1204)
Publication Publié, 1973

Article révisé par les pairs

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Résumé :

The effects of antilipolysis induced by nicotinic acid on the rates of turnover and oxidation of plasma glucose were studied in normal overnight fasted, obese overnight fasted, and obese starved subjects, using a 14C-glucose infusion technique. Changes induced by nicotinic acid were similar whatever the nutritional state of the subjects. Plasma FFA levels and blood concentrations of glycerol and ketones decreased by about 60%; glycemia remained essentially unchanged but both the removal rate of plasma glucose and the hepatic glucose output increased by about 25%. Moreover, the fraction of glucose taken up by tissues and promptly oxidized and the fraction of expired CO2 derived from plasma glucose increased, respectively, by 18% and 33%. This enhancement of glucose utilization occurred despite a small but significant decrease in plasma IRI concentration, indicating that nicotinic acid increased sensitivity to insulin. The above-mentioned results were obtained in 8 of the 10 patients studied. The remaining two subjects did not respond to the administration of nicotinic acid by any significant decrease in FFA nor in glycerol concentrations and showed no change in the rates of glucose turnover and oxidation. These data indicate that the effects of nicotinic acid on glucose metabolism may be partly mediated through changes in plasma FFA concentration and are consistent with the idea that the "glucose-fatty acid cycle" plays a significant role in the control of glucose metabolism in man. © 1973.