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Combination chemotherapy with 1-(2-chloroethyl-3-cyclohexyl-1-nitrosourea) (CCNU), vincristine and methotrexate in primary and metastatic brain tumors-A preliminary report

par Hildebrand, Jerzy ;Wagenknecht, Viktor L.;Michel, Jeffrey;Kenis, Yvon ;Brihaye, Jean
Référence European journal of cancer, 9, 9, page (627-634)
Publication Publié, 1973

Article révisé par les pairs

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Résumé :

Thirty-eight patients, 15 with recurrent primary brain tumors, 8 with breast carcinoma and 15 with lung carcinoma brain metastases were treated by a combination of 1-(2-chloroethyl-3-cyclohexyl-1-nitrosourea) (CCNU): 100 mg/m2 every 6 weeks; vincristine: 2 mg/m2 and methotrexate: 24 mg/m2 both given once a week for 4 weeks and subsequently once every 4 weeks. Dexamethasone: 10 mg/m2 per day was initiated concomitantly with chemotherapy and administered for 4 weeks. Chemotherapy was well tolerated. Objective remission, defined as clinical improvement present 6 weeks after complete discontinuation of dexamethasone and lasting for 4 weeks or more, was observed in 11 patients: 6 with primary brain tumors, 4 with breast carcinoma and 1 with lung carcinoma brain metastases. In 7 patients, the remissions were characterized by a remarkable functional recovery. EEG and brain scan appeared both as useful complementary examinations in the estimation of tumor size modifications. © 1973.