par Gallo, Rita;Grieco, Fabio Arturo 
;Marselli, Lorella;Ferretti, Elisabetta;Gulino, Alberto;Marchetti, Piero;Dotta, Francesco
Référence Annals of the New York Academy of Sciences, 1150, page (43-45)
Publication Publié, 2008-12
;Marselli, Lorella;Ferretti, Elisabetta;Gulino, Alberto;Marchetti, Piero;Dotta, FrancescoRéférence Annals of the New York Academy of Sciences, 1150, page (43-45)
Publication Publié, 2008-12
Article révisé par les pairs
| Résumé : | A detailed understanding of the molecular process involved in the proliferation of pancreatic precursor cells would provide key elements for developing new therapeutic strategies to cure type 1 diabetes. In the present study we investigated the potential involvement of hedgehog signaling in proliferating human pancreatic islet-derived mesenchymal (hPIDM) cells, a population of cells that can be successfully expanded and induced to differentiate into an insulin-secreting phenotype. Here we report that in these precursor cells a hedgehog signaling pathway is activated, as shown by Gli1 expression, and that a dose-dependent inhibition of such a pathway by cyclopamine results in a significant reduction of cell proliferation. |
