• Citer

Induction of progesterone receptor in an estrogen, progesterone receptor-negative breast cancer cell line

par Devleeschouwer, Nadine ;Olea-Serrano, Nicolás;Leclercq, Guy ;Legros, Nicole;Heuson, Jean-Claude
Référence Journal of Steroid Biochemistry, 24, 1, page (365-368)
Publication Publié, 1986

Article révisé par les pairs

• Accès en ligne
• Détails
• Contenu
• Statistiques

Résumé :

In MCF-7 cell culture, some sera endow estradiol-17β with strong growth promoting properties ("active" sera) while other fail to display this property ("inactive" sera). Passage from "inactive" to "active" sera are shown here to induce the appearance of a progestin binding capacity in the receptor negative line Evsa-T. Competition with various unlabeled steroids established the specificity of this binding reaction. The induction of progesterone receptor required neither estrogens, nor ER and failed to confer major growth sensitivity to hormonal steroids: only medroxyprogesterone acetate was slightly inhibitory at high concentration. These observations disclose the influence of seric factors independent of estrogens and of ER-related mechanisms on PgR induction. © 1986.