par Demanet, Jean Claude 
;Degaute, Jean-Paul ;Hubert, Claude
Référence Current medical research and opinion, 5, S1, page (129-136)
Publication Publié, 1977
;Degaute, Jean-Paul ;Hubert, Claude Référence Current medical research and opinion, 5, S1, page (129-136)
Publication Publié, 1977
Article révisé par les pairs
| Résumé : | Twenty-four patients with essential hypertension were included in a 3-year open study to assess the tolerance of 2.5 mg indapamide daily. In addition to changes in blood pressure, the effcts of indapamide on blood electrolytes, particularly potassium, and on uric acid, blood urea and creatinine were followed up regularly during the long study period. A parallel study was carried out under similar conditions in 52 hypertensive patients treated with the potassium-sparing diuretic combination of 50 mg hydrochlorothiazide plus 5 mg amiloride daily. The hypotensive effect of indapamide, comparable to that of the diuretic combination, remained unchanged with time and averaged 24 mmHg systolic and 13 mmHg diastolic in both supine and erect positions. Indapamide did not induce more hypokalaemiaa than hydrochlorothiazide plus amiloride, the mean decrease being approximately 0.3 mEq/l throughout treatment. No significant changes were observed in serum sodium and calcium, but there was a slight increase in blood urea without change in creatinine with both treatments. An increase in blood uric acid was also noted, the increase being less marked with indapamide. © 1977 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted. |
