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Double-blind comparison of the respiratory effects of parenteral lorazepam and diazepam in patients with chronic obstructive lung disease

par Denaut, M.;Yernault, Jean Claude ;De Coster, Armand
Référence Current medical research and opinion, 2, 10, page (611-615)
Publication Publié, 1975

Article révisé par les pairs

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Résumé :

The effects on the respiratory function of two tranquillising drugs, lorazepam and diazepam, have been compared in 20 patients with chronic obstructive lung disease. Both drugs induce a respiratory depression (decrease in tidal volume and minute ventilation with acceleration of the respiratory frequency) with slight respiratory acidosis, but lorazepam causes no significant hypoxemia and has a shorter duration of action than diazepam. Nevertheless, if tranquillisers are indicated in such patients, they have to be used with care. © 1975 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted.