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CA2+ ionophoretic properties of negative phospholipids in liposomes and in a pressman cell

par Deleers, Michel
Référence Archives of physiology and biochemistry, 92, 2, page (BP5-BP6)
Publication Publié, 1984

Article révisé par les pairs

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Résumé :

The ionophoretic properties of phospholipids in two phase bulk systems has been already demonstrated (Tysonet al., 1976). Phospholipids may also act synergistically with other ionophoretic molecules to translocate Ca2+ (deleers et al., 1983). Some products of the phospholipid metabolism in the lipoxygenase pathway were shown to transport Ca2+ in liposomes membranes (Serhanet al., 1982) and to form stable ionophoretic complexes (Brasseur & Deleers, 1984). However the action of pure phospholipids like phosphatidic acid or phosphatidyl serine as ionophores in lipid membranes remains a matter of debate (Serhan et al., 1981 & 1982; Holmes & Yoss, 1983). The aim of this work is to show that phosphatidic acid (PA), dipalmitoyl phosphatidic acid (DPPA), phosphatidyl serine (PS), diphosphatidyl glycerol (cardiolipin CL), phosphatidyl inositol (PI) and phosphatidyl inositol diphosphate (PIP2) may translocate Ca2+ in a two-phase bulk system. Under suitable conditions they may also transport Ca2+ to different extent through liposomes membranes. © 1984 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted.