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An EORTC gastrointestinal group phase II evaluation of epirubicin combined with 5-fluorouracil in advanced adenocarcinoma of the pancreas

par Wils, Jaques;Bleiberg, Harry ;Dalesio, Otilia;Duez, Nicole;Blijham, Geert;Planting, André S Th A.;Splinter, Ted;Weber, Walter
Référence European journal of cancer & clinical oncology, 23, 7, page (1017-1018)
Publication Publié, 1987

Article révisé par les pairs

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Résumé :

The EORTC Gastrointestinal Group has conducted a phase II trial in 47 patients with locally advanced or metastatic adenocarcinoma of the pancreas with epirubicin 90 mg/m2 intravenously on day 1 in combination with 5-fluorouracil 500 mg/m2 in a 2 hr infusion day 1-4, every 4 weeks. Of 43 evaluable patients there were six early deaths due to tumour progression and one due to a cerebrovascular accident. There were six partial responses for a response rate of 14% including early deaths. The median survival for all patients was 4 months. It is concluded that the addition of 5-fluorouracil to epirubicin does not appear to enhance the therapeutic results of epirubicin alone. © 1987.