par La Barre, Jean
Référence Thérapeutique, 51, 3, page (159-162)
Publication Publié, 1975
Article révisé par les pairs
Résumé : Mongrel dogs and beagle dogs, addicted to heroin by means of intraperitoneal injection of increasing doses of diacetyl morphine chlorhydrate (heroin) (5 to 20 mg. per day for 5 mth), when suddenly and completely weaned of this drug for two days exhibited a state of pronounced hyperexcitability which was recorded according to Desmarez' ergometric technique. These phenomena of hyperexcitability could be suppressed completely by administration of sulpiride in a dosage of 200 mg. per 10 kg. body weight. Complete detoxification of these heroin addicted dogs could be achieved by continuing the treatment with decreasing doses of sulpiride for a total of 14 days. These purely experimental observations might serve as a basis for clinical studies with a view to applying the treatment with decreasing doses of sulpiride in a detoxification cure of human heroin addicts.