par Casteleyn, Pierre Paul;Willems, Glenda 
Référence Journal of the National Cancer Institute, 55, 6, page (1383-1387)
Publication Publié, 1975
Référence Journal of the National Cancer Institute, 55, 6, page (1383-1387)
Publication Publié, 1975
Article révisé par les pairs
| Résumé : | Atrophic gastritis was induced in 7 mongrel dogs by explanting a full thickness wedge of vascularized mucosa from the gastric greater curvature onto the abdominal wall. Autoradiography of mucosal specimens was carried out after the iv injection of thymidine H3. The labeling index, S phase duration, and cell cycle time were measured in normal and explanted fundic mucosa. The spatial distribution histograms of the labeled cells showed an enlarged area of proliferation. As in human atrophic gastritis, proliferation was shifted toward the mucosal surface. Significantly higher labeling indices were observed in the atrophic mucosa. Shortening of the S phase duration and the cell cycle time was indicated by the curves of the labeled mitoses. Proliferative activity was significantly accelerated in this experimental model of atrophic gastritis. |
