par Manto, Mario 
;Sctta, Fabrizia;Legros, Benjamin ;Jacquy, Jean ;Godaux, Emile
Référence Archives of neurology, 56, 12, page (1497-1500)
Publication Publié, 1999-12
;Sctta, Fabrizia;Legros, Benjamin ;Jacquy, Jean ;Godaux, Emile Référence Archives of neurology, 56, 12, page (1497-1500)
Publication Publié, 1999-12
Article révisé par les pairs
| Résumé : | Objectives: To investigate the resetting effects of transcranial magnetic stimulation over motor cortex on orthostatic tremor, characterized by high-frequency electromyographic discharges in weight-bearing muscles, particularly orthostatic tremor (OT) associated with cerebellar cortical atrophy; and to compare our results with those obtained in primary OT, for which transcranial magnetic stimulation does not reset tremor Design: Study of 3 patients who clinically exhibited a sporadic pancerebellar syndrome associated with isolated cerebellar atrophy and features of OT. Setting: Research hospital. Main Outcome Measures: Electromyograms and transcranial magnetic stimulation studies with a resetting index calculated on the basis of the timing of measured bursts and predicted bursts for a magnetic stimulus given at increasing delays. Results: Surface electromyographic recordings in weight-bearing muscles showed tremor with a frequency of 14, 15, and 14 Hz in the 3 patients. Transcranial magnetic stimulus was able to reset OT. Resetting index was 0.72. Conclusions: Transcranial magnetic stimulus resets OT associated with cerebellar cortical atrophy, emphasizing the role of motor cortex in the genesis of OT associated with a cerebellar dysfunction. Our results argue in favor of a distinct pathophysiological mechanism of primary OT and OT associated with cerebellar cortical atrophy. |
