Article révisé par les pairs
Résumé : The effect of non-specific stimulation of the reticulo-endothelial system by Bacillus Calmette-Guérin (BCG) on growth of the DMBA-induced rat mammary tumor was studied after ovariectomy. BCG was administered at the nadir of tumor regression following ablation of the ovaries, either once as a single injection or at weekly intervals. Resumption of tumor growth, that occurred as expected in the untreated control group, was delayed at least three weeks after the single BCG injection and completely prevented when BCG was given weekly. These findings are discussed in relation to previous observations on the effect of BCG on mammary tumor growth in non-ovariectomized rats. © 1971.