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NF-κB inhibition impairs the radioresponse of hypoxic EMT-6 tumour cells through downragulation of inducible nitric oxide synthase

par De Ridder, Mark;Van Den Berge, Dirk L;Verovski, Valeri N;Monsaert, Christinne;Wauters, Nathalie;Storme, Guy
Référence British Journal of Cancer, 88, 1, page (120-124)
Publication Publié, 2003-01

Article révisé par les pairs

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Résumé :

Hypoxic EMT-6 tumour cells displayed a high level of inducible nitric oxide synthase (iNOS) and an increased radiosensitivity after a 16 h exposure to lipopolysaccharide, a known activator of nuclear factor-κB (NF-κB). Both iNOS activation and radioresponse were impaired by the NF-κB inhibitors phenylarsine oxide and lactacystin. Contrasting to other studies, our data show that inhibition of NF-κB may impair the radioresponse of tumour cells through downregulation of iNOS. © 2003 Cancer Research UK.