Chronic hypoxia modulates tumour cell radioresponse through cytokine-inducible nitric oxide synthase
par Van Den Berge, Dirk L;De Ridder, Mark;Verovski, Valeri N;Janssens, Marleen M.Y.;Monsaert, Christinne;Storme, Guy 
Référence British Journal of Cancer, 84, 8, page (1122-1125)
Publication Publié, 2001-04
Référence British Journal of Cancer, 84, 8, page (1122-1125)
Publication Publié, 2001-04
Article révisé par les pairs
| Résumé : | Chronic hypoxia up-regulated the mRNA and protein expression of inducible nitric oxide synthase (iNOS) in EMT-6 tumour cells exposed to interferon (IFN)-gamma and interleukin (IL)-I beta, Low concentrations of cytokines (1 unit ml-1) in 1% but not in 21% oxygen induced a remarkable increase in NO production and a 1.8-fold hypoxic cell radiosensitization. Therefore, chronic hypoxia may potentially be exploited to increase tumour cell radioresponse through the cytokine-inducible iNOS pathway. © 2001 Cancer Research Campaign. |
