• Citer

Macromolecular creatine kinase type 1: A serum marker associated with disease

par Laureys, Marc ;Sion, Jean Paul;Slabbynck, Hans;Steenssens, Laurette;Cobbaert, Christa;Derde, Marie Paule;Gorus, Frans
Référence Clinical chemistry, 37, 3, page (430-434)
Publication Publié, 1991

Article révisé par les pairs

• Détails
• Contenu

Résumé :

The prevalence of circulating macromolecular creatine kinase type 1 (macro CK type 1 or CK-immunoglobulin complexes) is significantly higher in a patient population selected for CK isoenzyme assay than in age- and sex-matched blood donors (n = 1304). In >8000 patients studied, 49 individuals with macro CK type 1 were identified, yielding an overall prevalence of 0.61%. Macro CK type 1 complexes occurred more frequently in women and in patients older than 70 years, and were often associated with complications of cardiovascular disease, life-threatening conditions, and poor outcome. These latter clinical associations could arise, at least partly, from the selection of patients for whom CK isoenzyme analysis was ordered.