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Regional chemotherapy of maxillofacial malignant melanoma with intracarotid artery infusion of DTIC

par Jortay, Albert ;Lejeune, Ferdinand ;Kenis, Yvon
Référence Tumori, 63, 3, page (299-302)
Publication Publié, 1977

Article révisé par les pairs

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Résumé :

Six intracarotid artery infusions of DTIC were performed in 4 patients with invasive malignant melanoma of the maxillo facial region. A total dose of 3.5 to 7 g was well tolerated. Only 1 patient (who received 9.5 g in 25 days) developed a reversible bone marrow depletion. Two of the 4 patients presented a transient 50% tumor surface regression, but no response was seen after the second infusion. Of the 2 remaining patients, 1 had no measurable effect and 1 experienced tumor progression.