Article révisé par les pairs
Résumé : Six intracarotid artery infusions of DTIC were performed in 4 patients with invasive malignant melanoma of the maxillo facial region. A total dose of 3.5 to 7 g was well tolerated. Only 1 patient (who received 9.5 g in 25 days) developed a reversible bone marrow depletion. Two of the 4 patients presented a transient 50% tumor surface regression, but no response was seen after the second infusion. Of the 2 remaining patients, 1 had no measurable effect and 1 experienced tumor progression.