par Genta-Jouve, Grégory;Ioannou, Efstathia;Mathieu, Véronique ;Bruyère, Céline ;Lefranc, Florence ;Thomas, Olivier O.P.;Kiss, Robert ;Roussis, Vassilios
Référence Phytochemistry Letters, 5, 4, page (747-751)
Publication Publié, 2012-12
Référence Phytochemistry Letters, 5, 4, page (747-751)
Publication Publié, 2012-12
Article révisé par les pairs
Résumé : | The absolute configuration of dilospirane B (1), a diterpene featuring a novel carbon framework recently isolated from the brown alga Dilophus spiralis, was established on the basis of theoretical calculations of its electronic circular dichroism spectra applying the time-dependent density functional theory method. Metabolite 1, evaluated for its in vitro antitumor activity against six human cancer cell lines displaying various levels of sensitivity to pro-apoptotic stimuli, exhibited growth inhibitory activity with a mean IC 50 value of 66 μM. Quantitative videomicroscopy analyses indicated that 1 initially displays cytostatic effects which later become cytotoxic. © 2012 Phytochemical Society of Europe. |