par Szeifert, Gyorgy ;Kondziolka, Douglas;Levivier, Marc ;Lunsford, Dade L.D.
Référence Progress in neurological surgery, 25, page (30-38)
Publication Publié, 2012
Article révisé par les pairs
Résumé : Histopathological investigations revealed acute-, subacute-, and chronic-type tissue responses, accompanied by inflammatory cell reaction in radiosurgery treated cerebral metastases originating from different primary cancers. Immunohistochemistry demonstrated that the preponderance of CD68-positive macrophages and CD3-positive T lymphocytes in the inflammatory infiltration developed in better controlled metastases (> 5 months). In contrast, it was sparse or absent in poorly controlled neoplasms (< 5 months) after radiosurgery. This inflammatory reaction may be stimulated by the ionizing energy, probably influenced by the general condition of the patients' immune system as well, and seems to play a role in local tumor control after focused radiation. Copyright © 2012 S. Karger AG, Basel.