Article révisé par les pairs
Résumé : The kinetics and dose dependence were determined both for the repair synthesis and for the induction and repair of single-strand breaks in the 5-bromodeoxyuridine-substituted DNA of ultraviolet-irradiated Chinese hamster cells. A close temporal relationship was observed between repair synthesis and break sealing. The induction of single-strand breaks was linear with dose, whereas a non-linear response was found for repair synthesis. Since almost all breaks were repaired, the calculated number of bases which could be inserted per repaired single-strand break depended on the dose and was close or inferior to a hundred. © 1974.