par Loos, Marleen;Delforge, Alain ;Mattelaer, Marie Anne
Référence Anticancer research, 1, 6, page (393-396)
Publication Publié, 1981
Référence Anticancer research, 1, 6, page (393-396)
Publication Publié, 1981
Article révisé par les pairs
Résumé : | Nocodazole, a water insoluble antimitotic drug active on L1210 leukemia was incorporated into liposomes, to investigate whether this procedure could increase cellular uptake. The effects of micronized nocodazole and liposome-entrapped nocodazole were compared on human marrow cells in vitro using a myeloid progenitor cell assay (CFU-C). The human CFU-C were sensitive to the micronized drug in a dose-related fashion. However, contrasting with a previous report on L1210 leukemia, entrapping of nocodazole into liposomes did not increase its activity on CFU-C of either normal or leukemic subjects. |