• Citer

Iodized oil as a complement to iodized salt in schoolchildren in endemic goiter in Romania

par Simescu, Mihaela;Varciu, M.;Nicolaescu, E.;Gnat, Danielle;Podoba, J.;Mihaescu, M.;Delange, François
Référence Hormone research, 58, 2, page (78-82)
Publication Publié, 2002

Article révisé par les pairs

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Résumé :

Objective: To evaluate the long-term efficacy and possible side effects of low doses of iodized oil on iodine nutrition and thyroid function in endemic goiter in Romania. Methods: Random selection of 214 schoolchildren aged 6-14 years. Serial measurements of urinary iodine, thyroid volume with ultrasound, serum concentrations of thyrotropin, free thyroxine, thyroglobulin and thyroid autoantibodies before and up to 2 years after the oral administration of 200 mg iodine in iodized oil. Results: Urinary iodine concentrations indicated a moderate iodine deficiency before therapy, sharply increased soon after therapy and slowly decreased thereafter but remained within the normal range up to more than 1 year after therapy. The prevalence of goiter was 29% before the administration of iodized oil and 9% 1 year later. Thyroid function tests and autoantibodies were normal before and up to 2 years after therapy. Conclusion: A single dose of 200 mg iodine from oral Lipiodol® appears adequate and safe for correcting moderate iodine deficiency in children. Copyright © 2002 S. Karger AG, Basel.