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Pulmonary mechanics and diffusing capacity in cystic fibrosis

par Baran, Dana;Englert, Marc
Référence Helvetica Paediatrica Acta, 28, 2, page (175-183)
Publication Publié, 1973

Article révisé par les pairs

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Résumé :

Lung function has been studied in 41 patients with cystic fibrosis, aged 5 to 21, with a complete battery of pulmonary function test. The data indicate that the measurements of maximal flow rates, particularly at small lung volumes, of plethysmographic functional residual capacity and of helium equilibration time might detect a pathological condition of the lungs of these patients at a stage when other tests give results close to normal limits. On the contrary, static compliance, static lung recoil pressure and diffusing capacity are seldon abnormal. These results are likely to be explained by the fact that the bronchial obstruction bound to viscous secretions constitutes the initial and constant manifestation in this disease, while the parenchymatous damage occurs only after a more or less long evolutive course and repeated inflammatory changes.