par Vainsel, Marc ;Bouillon, R.
Référence Revue médicale de Bruxelles, 16, 5, page (364-367)
Publication Publié, 1995
Article révisé par les pairs
Résumé : Resistance to vitamin D has been known of for a long time but was erroneously ascribed to phosphate deficiency (phosphate diabetes or deficiency in tubular phosphate reabsorption). True vitamin D resistance can either be due to lack of the receptor itself or to structural abnormality in the hormone- or DAN-binding site of the receptor whereas in a few cases post-receptor resistance has been documented. In view of the therapeutic consequences, diagnosis of vitamin D resistance is needed in every case of rickets not due to simple vitamin D deficiency. Such cases can be easily recognized by normal 25-hydroxyvitamin D concentration in the presence of biochemical, radiological and/or histological signs of rickets.