Article révisé par les pairs
|Blood lymphocytes from normal subjects were cultured with levamisole in the absence or presence of phytohemagglutinin (PHA). Levamisole, by itself, did not stimulate the lymphocytes. Levamisole, at 10-3 mg/100 ml, significantly increased the response to the mitogen. Other concentrations (from 1 mg to 10-8 mg/100 ml) did not alter the response to PHA. The same effect, at the same concentration, was observed for isolated blood T cell rich populations in presence of PHA. Levamisole did not modify the PHA response of T cell poor populations. These experiments suggest that levamisole has an action on human T lymphocytes.