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Palmitate induces a pro-inflammatory response in human pancreatic islets that mimics CCL2 expression by beta cells in type 2 diabetes.

par Igoillo Esteve, Mariana ;Marselli, L;Andrade Da Cunha, Daniel ;Ladrière, Laurence ;Ortis, Fernanda ;Grieco, Fabio Arturo ;Dotta, F;Weir, G.;Marchetti, Piero;Eizirik, Decio L. ;Cnop, Miriam
Référence Diabetologia, 53, 7, page (1395-1405)
Publication Publié, 2010

Article révisé par les pairs

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Résumé :

Beta cell failure is a crucial component in the pathogenesis of type 2 diabetes. One of the proposed mechanisms of beta cell failure is local inflammation, but the presence of pancreatic islet inflammation in type 2 diabetes and the mechanisms involved remain under debate.