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Interleukin-9 stimulates the production of interleukin-5 in CD4+ T cells.

par Poulin, Lionel F;Habran, Claude;Stordeur, Patrick ;Goldman, Michel ;McKenzie, Andrew;Van Snick, Jacques;Renauld, Jean-Christophe;Braun, Michel Y
Référence European cytokine network, 16, 3, page (233-239)
Publication Publié, 2005-09

Article révisé par les pairs

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Résumé :

We recently showed that interleukin-9 (IL-9), a Th2 cytokine, promotes IL-5-mediated rejection of allografts in mice. This observation led us to investigate the functional link between IL-9 and IL-5 production during alloreactive T cell responses in vitro and in vivo. Firstly, we found that IL-9 was produced by alloreactive Th2 cells, and IL-9 mRNA was detected in skin allograft during Th2-type rejection. We then established that IL-5 production was impaired in alloreactive Th2 cells isolated from IL-9-deficient mice and that optimal IL-5 production after allogeneic stimulation requires a functional IL-9 receptor (IL-9R) on the responding cells. Finally, the production of IL-5 by anti-CD3-stimulated CD4+ T cells was abolished by neutralization of IL-9. Despite the fact that IL-9 promotes IL-5 production by alloreactive T cells, IL-9-deficient recipients of skin allografts still developed eosinophilic graft infiltrates and neither IL-9 nor IL-9R deficiency modified Th2-type allograft rejection.