par Babina, Irina S;McSherry, E A;Donatello, Simona ;Hill, Arnold D K;Hopkins, Ann M
Référence Breast cancer research, 16, 1, page (R19)
Publication Publié, 2014-02
Référence Breast cancer research, 16, 1, page (R19)
Publication Publié, 2014-02
Article révisé par les pairs
Résumé : | Most breast cancer-related deaths result from metastasis, a process involving dynamic regulation of tumour cell adhesion and migration. The adhesion protein CD44, a key regulator of cell migration, is enriched in cholesterol-enriched membrane microdomains termed lipid rafts. We recently reported that raft affiliation of CD44 negatively regulates interactions with its migratory binding partner ezrin. Since raft affiliation is regulated by post-translational modifications including palmitoylation, we sought to establish the contribution of CD44 palmitoylation and lipid raft affiliation to cell migration. |