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Automated quantification of serum hyaluronic acid for non-invasive assessment of liver fibrosis in chronic hepatic diseases

par Lazarova, Elena ;Fernandez, M.Y.V;Adler, Michael ;Gulbis, Béatrice
Référence Immuno analyse & biologie spécialisée, 26, 5-6, page (217-224)
Publication Publié, 2011

Article révisé par les pairs

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Résumé :

To assess liver fibrosis, we evaluated automated serum hyaluronic acid (HA) measurement alone or included in the Hepascore in 130 patients with different chronic liver diseases (CLD). We confronted HA with Fibrotest, and, when available, with transient elastography (Fibroscan) and liver biopsy used for liver fibrosis diagnosis. HA was the only biomarker showing difference between " advanced fibrosis" and " cirrhosis" , Hepascore and Fibrotest being significantly different only between the groups " cirrhosis" and " lack of fibrosis" defined by Fibroscan or by biopsy. For cirrhosis, HA less than 65. ng/mL correctly identified non-cirrhotic patients in 96% of the cases while HA greater than 175. ng/mL correctly identified cirrhotic patients in 81% of the cases. For fibrosis, the cut-off of 115. ng/mL showed a positive predictive value of 90%. Here we demonstrate that HA alone or included in Hepascore reveals a good ability to detect all stages of CLD, especially to exclude cirrhosis from advanced fibrosis. HA assay might be used to evaluate liver fibrosis in complement to other non-invasive diagnostic markers. © 2011 Elsevier Masson SAS.