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Cyclosporine nephropathy after heart and heart-lung transplantation

par Goldstein, Jacques ;Thoua, Yvette ;Wellens, Francis;Leclerc, Jean Louis ;Vanherweghem, Jean-Louis ;Vereerstraeten, Pierre ;Primo, G.;Toussaint, Charles
Référence Proceedings of the European Dialysis and Transplant Association (1964), Vol. 21, page (973-980)
Publication Publié, 1984

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Résumé :

Cyclosporine nephrotoxicity after heart transplantation can lead to acute renal failure requiring haemodialysis. In four long-term heart-transplant survivors, cyclosporine nephropathy was characterised by extensive fibrosis, with uraemia, hypertension and/or anaemia. In contrast, the long-term survivor of heart-lung transplantation who had received her graft for accelerated respiratory failure, did not develop chronic renal disease. Thus, chronically reduced renal perfusion before heart transplantation may play a critical role in the development of chronic cyclosporine nephropathy.