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CD5 expression promotes multiple intracellular signaling pathways in B lymphocyte.

par Mageed, Rizgar A;Garaud, Soizic ;Taher, Taher E;Parikh, Kaushal;Pers, Jacques-Olivier;Jamin, Christophe;Renaudineau, Yves;Youinou, Pierre
Référence Autoimmunity Reviews, 11, 11, page (795-798)
Publication Publié, 2012-09

Article révisé par les pairs

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Résumé :

CD5(+) B lymphocytes have distinct functional properties compared with B lymphocytes that lack CD5. However, it remains unclear if and how the CD5 molecule modulates B lymphocyte biology and responses. Our recent studies have revealed that CD5 promotes constitutive activation of multiple signaling pathways including extracellular signal-regulated kinases (ERK1/2), phosphatidylinositol 3-kinase (PI-3K)/mammalian target of rapamycin (mTOR) and calcineurin-NFAT signaling pathways. Further, changes in cytokine production including the production of IL-10 are related to the activation of the transcription factors NFAT2 and STAT3. All in all, these studies provide a framework for understanding how CD5 impacts B lymphocyte biology and responses.