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A fatal case of cutaneous adverse drug-induced toxic epidermal necrolysis associated with severe rhabdomyolysis.

par Noordally, Sheik Oaleed ;Sohawon, Schoeb;Vanderhulst, Julien ;Duttmann, Ruth;Corazza, Francis ;Devriendt, Jacques
Référence Annals of saudi medicine, 32, 3, page (309-311)
Publication Publié, 2012

Article révisé par les pairs

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Résumé :

Toxic epidermal necrolysis represents an immunologic reaction to a foreign antigen and is most often caused by drugs. Atorvastatin, a blood cholesterol-lowering agent, is a recognized cause of rhabdomyolysis; while naproxen, a widely used nonsteroidal anti-inflammatory drug, is a known cause of photo-induced skin lesions. We report the first fatal case of drug-induced toxic epidermal necrolysis associated with severe muscle necrosis due to the use of a nonsteroidal anti-inflammatory drug and a statin with very high levels of creatine phosphokinase leading to acute kidney injury, disseminated intravascular coagulation, and complete skin necrosis leading to death.