par Devreker, Fabienne 
;Govaerts, Isabelle;Bertrand, Evelyne ;Van Den Bergh, Marc Jg;Gervy, Catherine;Englert, Yvon
Référence Fertility and sterility, 65, 1, page (122-126)
Publication Publié, 1996
;Govaerts, Isabelle;Bertrand, Evelyne ;Van Den Bergh, Marc Jg;Gervy, Catherine;Englert, Yvon Référence Fertility and sterility, 65, 1, page (122-126)
Publication Publié, 1996
Article révisé par les pairs
| Résumé : | Objectives: To determine the efficacy and innocuousness of long-acting versus short-acting GnRH analogues (GnRH-a) in long protocol for in IVF-ET. Design: Prospective randomized study. Setting: The IVF unit at an academic hospital. Patients: One hundred couples admitted for their first IVF-ET attempt. Main Outcome Measures: Serum concentrations of LH, E2, and P during the all cycles and duration of pituitary desensitization were assessed, as well as fertilization rate, embryo quality, and implantation and pregnancy rates. Results: Significantly more days (10.8 ± 1.8 versus 9.2 ± 1.7 days) of stimulation and more ampules of hMG (47 ± 22 versus 33 ± 16) were necessary to obtain similar numbers of embryos of quality with the long- acting GnRH-a. Implantation and delivery rates were significantly lower with the long-acting GnRH-a (32.8% versus 21.1%; 48.9% versus 29.1%, respectively). Conclusions: As the long-acting GnRH-a might interfere with the luteal phase and embryo development, short-acting GnRH-a should be preferred for ovarian hyperstimulation in IVF-ET. |
