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AMD3100 disrupts the cross-talk between chronic lymphocytic leukemia cells and a mesenchymal stromal or nurse-like cell-based microenvironment: pre-clinical evidence for its association with chronic lymphocytic leukemia treatments.

par Stamatopoulos, Basile ;Meuleman, Nathalie ;De Bruyn, Cécile ;Pieters, Karlien ;Mineur, Philippe;Le Roy, Christine;Saint-Georges, Stéphane;Varin-Blank, Nadine;Cymbalista, Florence;Bron, Dominique ;Lagneaux, Laurence
Référence Haematologica, 97, 4, page (608-615)
Publication Publié, 2012-04

Article révisé par les pairs

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Résumé :

Interactions with the microenvironment, such as bone marrow mesenchymal stromal cells and nurse-like cells, protect chronic lymphocytic leukemia cells from spontaneous and drug-induced apoptosis. This protection is partially mediated by the chemokine SDF-1α (CXCL12) and its receptor CXCR4 (CD184) present on the chronic lymphocytic leukemia cell surface.