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AMD3100 disrupts the cross-talk between chronic lymphocytic leukemia cells and a mesenchymal stromal or nurse-like cell-based microenvironment: pre-clinical evidence for its association with chronic lymphocytic leukemia treatments.

par Stamatopoulos, Basile ;Meuleman, Nathalie ;De Bruyn, Cécile ;Pieters, Karlien ;Mineur, Philippe;Le Roy, Christine;Saint-Georges, Stéphane;Varin-Blank, Nadine;Cymbalista, Florence;Bron, Dominique ;Lagneaux, Laurence
Référence Haematologica, 97, 4, page (608-615)
Publication Publié, 2012-04

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Titre:	AMD3100 disrupts the cross-talk between chronic lymphocytic leukemia cells and a mesenchymal stromal or nurse-like cell-based microenvironment: pre-clinical evidence for its association with chronic lymphocytic leukemia treatments.
Auteur:	Stamatopoulos, Basile; Meuleman, Nathalie; De Bruyn, Cécile; Pieters, Karlien; Mineur, Philippe; Le Roy, Christine; Saint-Georges, Stéphane; Varin-Blank, Nadine; Cymbalista, Florence; Bron, Dominique; Lagneaux, Laurence
Informations sur la publication:	Haematologica, 97, 4, page (608-615)
Statut de publication:	Publié, 2012-04
Sujet CREF:	Cancérologie
Mots-clés:	Amd3100
	Apoptosis
	Chronic lymphocytic leukemia
	Mesenchymal stromal cells
	Microenvironment
	Nurse-like cells
MeSH keywords:	Actins -- metabolism
	Antibodies, Monoclonal -- immunology -- metabolism
	Antineoplastic Agents -- pharmacology -- therapeutic use
	Apoptosis -- drug effects
	Cell Communication -- drug effects
	Cell Movement -- drug effects
	Cell Survival -- drug effects
	Chemokine CXCL12 -- pharmacology
	Coculture Techniques
	Heterocyclic Compounds -- pharmacology -- therapeutic use
	Humans
	Leukemia, Lymphocytic, Chronic, B-Cell -- drug therapy -- metabolism
	Leukocytes, Mononuclear -- drug effects -- metabolism
	Mesenchymal Stromal Cells -- drug effects -- metabolism
	Protein Binding -- drug effects -- immunology
	Protein Multimerization -- drug effects
	Receptors, CXCR4 -- antagonists & inhibitors -- immunology -- metabolism
	Tumor Microenvironment -- drug effects
Note générale:	Journal Article
	Research Support, Non-U.S. Gov't
	SCOPUS: ar.j
Langue:	Anglais
Identificateurs:	urn:issn:0390-6078
	info:doi/10.3324/haematol.2011.052779
	info:pii/haematol.2011.052779
	info:scp/84859463308
	info:pmid/22058221
	PMC3347654