• Citer

A phase II randomized study of combined infusional leucovorin sodium and 5- FU versus the leucovorin calcium followed by 5-FU both in combination with irinotecan or oxaliplatin in patients with metastatic colorectal cancer.

par Bleiberg, Harry ;Vandebroek, A;Deleu, I;Vergauwe, Philippe;Rezaei Kalantari, H;D'Haens, Geert;Paesmans, Marianne ;Peeters, Marc;Efira, André ;Humblet, Yves
Référence Acta gastro-enterologica Belgica (Ed. multilingue), 75, 1, page (14-21)
Publication Publié, 2012-03

Article révisé par les pairs

• Détails
• Contenu

Résumé :

Leucovorin Sodium (LV/Na) has a high solubility, and is stable when given with continuous infusion of 5-FU. It could maintain significant plasma concentration of 5, 10-meTHF during the whole 5-FU perfusion with the potential of increasing 5-FU cytotoxicity. We conducted a randomized phase II clinical trial on leucovorin calcium (LV/Ca) and LV/Na in metastatic colorectal cancer patients (mCRC). Main objectives were to assess efficacy and safety.