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The effects of etomidate on adrenal responsiveness and mortality in patients with septic shock.

par Cuthbertson, B H;Sprung, Charles;Annane, Djillali;Chevret, Sylvie;Garfield, Mark;Goodman, Stephen;Laterre, Pierre-Francois;Vincent, Jean Louis ;Freivogel, Klaus;Reinhart, Konrad;Singer, Mervyn;Payen, Didier;Weiss, Y G
Référence Intensive care medicine, 35, 11, page (1868-1876)
Publication Publié, 2009-11

Article révisé par les pairs

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Résumé :

Use of etomidate in the critically ill is controversial due to its links with an inadequate response to corticotropin and potential for excess mortality. In a septic shock population, we tested the hypotheses that etomidate administration induces more non-responders to corticotropin and increases mortality and that hydrocortisone treatment decreases mortality in patients receiving etomidate.