Résumé : This article offers a conceptual analysis of the negotiation of the Comprehensive Economic and Trade Agreement (CETA) between Canada and the European Union. It argues that traditional accounts of the structure of trade negotiations must be tailored for their novel nature, especially their wider scope on various regulatory issues and the relative economic weight of trading partners. To build our argument, we revisit traditional structural factors such as economic interdependence, non-agreement alternatives (NAA), institutional constraints, outcome valuations, and domestic support. We conclude that current and future bilateral trade negotiations will likely last longer, deadlocks will likely become more frequent, and that variations in scope will likely increase. © 2012 Koninklijke Brill NV, Leiden.