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Insufficient β-lactam concentrations in the early phase of severe sepsis and septic shock.

par Taccone, Fabio ;Laterre, Pierre-Francois;Dugernier, Thierry;Spapen, H.;Delattre, Isabelle Karine;Wittebole, Xavier;De Backer, Daniel ;Layeux, B;Wallemacq, Pierre;Vincent, Jean Louis ;Jacobs, Frédérique
Référence Critical care, 14, 4, page (R126)
Publication Publié, 2010

Article révisé par les pairs

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Résumé :

Altered pharmacokinetics (PK) in critically ill patients can result in insufficient serum β-lactam concentrations when standard dosages are administered. Previous studies on β-lactam PK have generally excluded the most severely ill patients, or were conducted during the steady-state period of treatment. The aim of our study was to determine whether the first dose of piperacillin-tazobactam, ceftazidime, cefepime, and meropenem would result in adequate serum drug concentrations in patients with severe sepsis and septic shock.