• Citer

Serum cytokine levels in human septic shock. Relation to multiple-system organ failure and mortality.

par Pinsky, Michaël ;Vincent, Jean Louis ;Devière, Jacques ;Alegre, Maria-Luisa ;Kahn, Robert ;Dupont, Etienne
Référence Chest, 103, 2, page (565-575)
Publication Publié, 1993-02

Article révisé par les pairs

• Détails
• Contenu

Résumé :

Cytokines have been associated with the development of sepsis and diffuse tissue injury following septic or endotoxic challenges in humans. Furthermore, relative organ-system dysfunction, not specific organ dysfunction, appears to predict outcome from critical illness. We hypothesized that persistence of inflammatory cytokines within the circulation, reflecting a generalized systemic inflammatory response, is associated with multiple-system organ failure (MSOF) and death from critical illness. In addition, since hepatic function is central to host-defense homeostasis, we further reasoned that critically ill patients with hepatic cirrhosis would have an increased incidence of MSOF and death following sepsis associated with a persistence of cytokines in the blood.