Increased expression of advanced glycation end-products and their receptor, and activation of nuclear factor kappa-B in lacrimal glands of diabetic rats.

Alves, M.-P.; Calegari, V C; Andrade Da Cunha, Daniel; Saad, M J A; Velloso, L A; Rocha, Eduardo M

doi:doi/10.1007/s00125-005-0010-9

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Increased expression of advanced glycation end-products and their receptor, and activation of nuclear factor kappa-B in lacrimal glands of diabetic rats.

par Alves, M.-P.;Calegari, V C ;Andrade Da Cunha, Daniel

;Saad, M J A ;Velloso, L A ;Rocha, Eduardo M
Référence Diabetologia, 48, 12, page (2675-2681)
Publication Publié, 2005-12

Article révisé par les pairs

Résumé :

To assess the involvement of the AGE-specific receptor (AGER, also known as RAGE) axis and nuclear factor kappa-B (NFKB, also known as NF-kappaB) activation in the development of lacrimal gland and tear film dysfunction in diabetes, the present study evaluated: (1) lacrimal gland and tear film alterations in diabetic rats; and (2) the expression of AGE, AGER and NFKB in ocular tissues of normoglycaemic and diabetic rats.

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