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Influence of Chloramphenicol on the sensitivity of Pseudomonas aeruginosa to chloroxylenol and crystal violet

par Boussard, Paule ;Devleeschouwer, Michel ;Otten, Martine ;Crotteux, Jeanne
Référence International journal of pharmaceutics, 32, page (91-92)
Publication Publié, 1986

Article révisé par les pairs

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Résumé :

Gustafson and co-workers (1973) in a study on Escherichia coli show that the chloramphenicol inhibition on protein synthesis opens also the outer membrane barrier to crystal violet. There is evidence that crystal violet and chloroxylenol, two hydrophobic molecules (Nikaido, 1976; Kropinski et al., 1978) cross the outer membrane of Pseudomonas aeruginosa by a particular pathway. These observations were made in our study on the sensitivity of Pseudomonas aeruginosa to antibacterials according to the growth conditions. The data show a resistance to chloroxylenol and crystal violet when the organism is grown in tryptic soy broth (T.S.B. Difco) and a sensitivity to these products when the bacteria is grown in brain heart infusion (B.H.I. Difco) (Devleeschouwer et al., submitted). It seemed thus interesting to look if a pretreatment of the strain with chloramphenicol would restore the sensitivity to chloroxylenol and crystal violet of the bacteria grown in T.S.B. © 1986.