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Probable hypersensitivity reaction to vancomycin associating rash, fever and neutropenia.

par Dauby, Nicolas ;Fink, Wolfram ;Seyler, L;Luce, Sylvie ;Nouwynck, Claire ;Tas, Saïd ;Jacobs, Frédérique
Référence Acta clinica Belgica (Ed. multilingue), 67, 3, page (226-228)
Publication Publié, 2012

Article révisé par les pairs

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Résumé :

We describe the case of a 54-year old woman with breast cancer who was treated by vancomycin for febrile neutropenia due to a methicillin-resistant Staphyloccocus epidermidis infection of a surgically implanted catheter. She developed an hypersensitivity reaction to vancomycin associating neutropenia, fever, skin rash and elevated liver enzymes following re-challenge with vancomycin after having been misdiagnosed with septic thrombophlebitis. Following this re-challenge, neutrophils count fell dramatically but promptly resolved after cessation of vancomycin.