par Ouattara, Basile 
;Jansen, Olivia;Angenot, Luc;Guissou, Innocent ;Frédérich, Michel;Fondu, Pierre ;Tits, Mathieu
Référence Phytomedicine, 16, 2-3, page (125-129)
Publication Publié, 2009-03
;Jansen, Olivia;Angenot, Luc;Guissou, Innocent ;Frédérich, Michel;Fondu, Pierre ;Tits, Mathieu Référence Phytomedicine, 16, 2-3, page (125-129)
Publication Publié, 2009-03
Article révisé par les pairs
| Résumé : | Fagara zanthoxyloides Lam. (syn. Zanthoxylum zanthoxyloides) (Rutaceae) is the most cited Fagara species for the treatment and the prevention of sickle cell disease crisis. Sickle cell anemia (SCA) is a public health problem in many countries particularly in Africa. The present study was designed to evaluate the antisickling properties of three isomeric divanilloylquinic acids (3,4-O-divanilloylquinic acid or burkinabin A; 3,5-O-divanilloylquinic acid or burkinabin B and 4,5-O-divanilloylquinic acid or burkinabin C) identified previously by LC/MS/NMR analysis in the root bark of F. zanthoxyloides [Ouattara et al., 2004. LC/MS/NMR analysis of isomeric divanilloylquinic acids from the root bark of Fagara zanthoxyloides Lam. Phytochemistry 65, 1145-1151]. The three isomers showed interesting antisickling properties which increased from burkinabins A to C. © 2008 Elsevier GmbH. All rights reserved. |
