par Le Buanec, Hélène 
;Lachgar, Abderrahim;D'Anna, Rossella;Zagury, Jean-François;Bizzini, Bernard;Bernard, Jacky;Ittelé, Daniéle;Hallez, Sophie ;Giannouli, Christina ;Burny, Arsène ;Zagury, Daniel
Référence Biomedicine & pharmacotherapy, 53, 7, page (323-328)
Publication Publié, 1999-08
;Lachgar, Abderrahim;D'Anna, Rossella;Zagury, Jean-François;Bizzini, Bernard;Bernard, Jacky;Ittelé, Daniéle;Hallez, Sophie ;Giannouli, Christina ;Burny, Arsène ;Zagury, DanielRéférence Biomedicine & pharmacotherapy, 53, 7, page (323-328)
Publication Publié, 1999-08
Article révisé par les pairs
| Résumé : | The human papillomavirus type 16 (HPV-16) E7 oncogenic protein is found in the culture supernatant of SiHa cells, a cervical carcinoma cell line. Extracellular E7 protein, acting as a viral toxin in human immune cells, induces the overproduction of the immune suppressive IFN-α cytokine by APCs, and inhibits the T-cell response to recall and allogenic antigens. These effects should be taken into account for the design of anti-human cervical carcinoma vaccines. |
