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The solution structure of the bovine leukaemia virus matrix protein and similarity with lentiviral matrix proteins

par Matthews, Steven;Mikhailov, Michael;Burny, Arsène ;Roy, Polly
Référence EMBO journal, 15, 13, page (3267-3274)
Publication Publié, 1996-07

Article révisé par les pairs

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Résumé :

In the mature virion, retroviral matrix proteins are found in association with the inner face of the viral membrane. They play a critical role in determining the morphogenesis of virus assembly. We have determined the three-dimensional solution structure of the bovine leukaemia virus (BLV) matrix protein by heteronuclear nuclear magnetic resonance. The protein contains four principal helices that are joined by short, partially structured loops. Despite no sequence similarity with the lentiviruses, the structure shows an intriguing homology with the equivalent protein from the human and simian immunodeficiency viruses. A root-mean-square deviation of 3.78 angstrom is observed over the backbone atoms of 36 equivalent helical positions. The similarity implies a possible common assembly unit for the matrix proteins of type C retroviruses.