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T-cell large granular lymphocyte leukemia is characterized by massive TCRBV-restricted clonal CD8 expansion and a generalized overexpression of the effector cell marker CD57.

par Melenhorst, Jos;Eniafe, Rhoda;Follmann, Dean;Molldrem, Jeffrey;Kirby, Martha;El Ouriaghli, Frank ;Barrett, A John
Référence Hematology journal, 4, 1, page (18-25)
Publication Publié, 2003

Article révisé par les pairs

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Résumé :

Large granular lymphocyte leukemia (LGL) is a clonal lymphoproliferative disease of CD8+ T cells expressing the CD57 activation marker. It is, however, unknown whether the CD57+ population represents the LGL clone or not. We previously demonstrated that the clone can be found in both CD8+CD57+ and CD8+CD57- cells, indicating that the LGL clone also resides in the CD57- fraction.